EDA-A1, Soluble (human) (rec.)-其他重组蛋白-深圳欣博盛生物科技有限公司

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EDA-A1, Soluble (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0106Y-C010	规格：10 ug	目录价：￥2160
货号：AG-40B-0106Y-3010	规格：3 x 10 ug	目录价：￥4320

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

EDA-A1, Soluble (human) (rec.)

别名:

Ectodysplasin-A; Ectodermal Dysplasia Protein

产品描述:

The TNF family ligand ectodysplasin A (EDA) and its receptor EDAR are required for proper development of skin appendages such as hair, teeth, and eccrine sweat glands. Loss of function mutations in the Eda gene cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition that can be ameliorated in mice and dogs by timely administration of recombinant EDA. The Eda gene on the X chromosome is transcribed as multiple splice variants, only two of which code for the receptor-binding C-terminal TNF homology domain. These two variants code for 391- and 389-amino acid-long proteins called EDA1 and EDA2. EDA1 binds EDAR, whereas EDA2 binds to another receptor, XEDAR. The biology of EDA2 and XEDAR is distinct from that of EDA1. Indeed, XEDAR-deficient mice have no obvious ectodermal dysplasia phenotype, whereas mice deficient in EDA, EDAR, or the signaling adaptor protein EDARADD all display virtually indistinguishable ectodermal dysplasia phenotypes, indicating the predominance of the EDA1-EDAR axis in the development of skin-derived appendages.

宿主来源:

HEK 293 cells. Produced using animal component-free medium.

靶标/特异性:

Binds to human and mouse EDAR (ectodysplasin-A1 receptor).

产品浓度:

0.1mg/ml after reconstitution.

保存温度:

+4°C

运输温度:

预期分子量:

~19kDa (SDS-PAGE) (non-glycosylated form) and ~24 kDa (glycosylated form)

产品形式: