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折扣/货期| 货号：23328-1 mg | 规格：1 mg | 目录价：￥670 |
| 货号：23328-10 mg | 规格：10 mg | 目录价：￥1997 |
| 货号：23328-5 mg | 规格：5 mg | 目录价：￥1327 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
EDO-S101
别名:
Tinostamustine
产品描述:
An HDAC inhibitor and DNA alkylating agent; inhibits class I and II HDACs (IC50s = 9-107 nM for HDAC1-3, 6, 8, and 10); inhibits HDAC activity in rat PBMCs ex vivo by 90% after a single dose of 10 mg/kg; induces formation of DNA crosslinks and double-strand breaks in HL-60 cells; reduces growth of MM cell lines irrespective of p53 mutational status or established resistance to DNA alkylating agents (IC50s = 1.6-4.8 μM); induces MM cell death ex vivo in bone marrow samples isolated from patients with early- and late-stage MM; reduces tumor growth and prolongs survival in an MM1S end-stage mouse xenograft model when administered at a dose of 60 mg/kg per week; prolongs survival in a multidrug resistant Vk12653 mouse transplant model of refractory MM
保存温度:
-20
运输温度:
-20
预期分子量:
415.4
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
1236199-60-2
分子式:
C19H28Cl2N4O2
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