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折扣/货期| 货号：16970-10 mg | 规格：10 mg | 目录价：￥1407 |
| 货号：16970-25 mg | 规格：25 mg | 目录价：￥2452 |
| 货号：16970-5 mg | 规格：5 mg | 目录价：￥844 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
EPI-001
产品描述:
An androgen receptor antagonist (IC50 = ~6 μM for inhibition of transactivation of the androgen receptor NTD); inhibits androgen-, FSK-, and IL-6-induced, as well as ligand-independent, PSA reporter gene expression in LNCaP cells expressing either the full length androgen receptor or a constitutively active mutant that lacks the ligand binding domain in a dose-dependent manner; inhibits androgen receptor interaction with the PSA androgen response element and blocks androgen-stimulated induction of endogenous PSA and 17 other androgen regulated genes in LNCaP cells; inhibits androgen-dependent and -independent growth of LNCaP and MDA-PCa-2B cells, but not 22Rv1, DU145, or PC3 cells that do not express the androgen receptor; reduces serum PSA and tumor growth in an LNCaP prostate cancer xenograft model in castrated mice when administered at a dose of 50 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
394.9
产品形式:
A crystalline solid
纯度:
≥95%
CAS号:
227947-06-0
分子式:
C21H27ClO5
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