ERAS Antibody / GTPase ERas-多抗-深圳欣博盛生物科技有限公司

首页产品中心多抗

ERAS Antibody / GTPase ERas

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：F54697-0.08ML	规格：0.08 ml	目录价：￥2962.25
货号：F54697-0.4ML	规格：0.4 ml	目录价：￥6343.55

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

ERAS Antibody / GTPase ERas

产品描述:

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Point mutations of several amino acids of human RAS, including gly12, ala59, or glu63, render the protein constitutively active. Embryonic stem cell-expressed Ras (ERAS) has serine, alanine, and asparagine at the positions corresponding to gly12, ala59, and glu63 of human RAS, suggesting that it is constitutively active.The PI3K (phosphoinositide 3-kinase) pathway is important for proliferation, survival and maintenance of pluripotency in ES cells. The PI3K pathway is activated by growth factors and cytokines including insulin and leukaemia inhibitory factor. In addition to these exogenous factors, the PI3K pathway is endogenously activated by the constitutively active Ras family protein ERas (ES cell-expressed Ras). ERas null ES cells maintained pluripotency but show significantly reduced growth and tumorigenicity, which can be rescued by expression of ERas cDNA or by activated phosphatidylinositol 3-hydroxykinase. The transforming oncogene ERAS appears to be important in the tumor-like growth properties of ES cells.

反应种属:

Human

宿主来源:

Rabbit

实验应用:

FACS, IF, IHC-P, WB

同种型:

Rabbit Ig

免疫原:

A portion of amino acids 13-42 from the human protein was used as the immunogen for the ERAS antibody.

克隆性:

Polyclonal (rabbit origin)