Eukaryotic translation initiation factor 5A-1 Antibody / EIF5A-多抗-深圳欣博盛生物科技有限公司

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Eukaryotic translation initiation factor 5A-1 Antibody / EIF5A

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：RQ6981

规格：100 ug

目录价：￥6488.05

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Eukaryotic translation initiation factor 5A-1 Antibody / EIF5A

产品描述:

Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. Eukaryotic initiation factor 5A (eIF5A) is an mRNA-binding protein that is involved in translation elongation and plays an important role in promoting translation of polyproline motifs. The eIF5A (eIF5A1) and eIF5A2 genes encode the two vertebrate eIF5A isoforms. While eIF5A1 is expressed constitutively in all tissues, eIF5A2 is mainly expressed in gonads. eIF5A and eIF5A2 are the only identified proteins that contain the distinctive amino acid hypusine, which is generated posttranslationally from lysine through a highly conserved polyamine metabolism pathway. eIF5A function and hypusine modification are both essential for cell proliferation, as knock down of eIF5A expression or blocking eIF5A hypusine modification suppresses cancer cell proliferation. Interestingly, eIF5A is an identified component of a tumor suppressor network of the polyamine-hypusine axis. Co-suppression of both eIF5A and adenosylmethionine decarboxylase 1 (AMD1) promotes lymphomagenesis in mice, while heterozygous deletions of the corresponding AMD1 and eIF5A genes often occur together in human lymphomas.

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

WB, IHC-P, IF, FACS, Direct ELISA

同种型:

Rabbit IgG

免疫原:

Recombinant human protein (amino acids R86-K154) was used as the immunogen for the EIF5A antibody.

克隆性:

Polyclonal (rabbit origin)

纯化方式:

Antigen affinity purified

保存温度:

After reconstitution, the Eukaryotic translation initiation factor 5A-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

产品形式:

Antigen affinity purified

存储溶液:

0.5mg/ml if reconstituted with 0.2ml sterile DI water

产地:

美国

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