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折扣/货期| 货号：60-904 | 规格：400 ul | 目录价：￥8687.25 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
F13B Antibody
别名:
Coagulation factor XIII B chain, Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain, F13B
反应种属:
Human,Mouse
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit Ig
克隆性:
Polyclonal
纯化方式:
This antibody is purified through a protein A column, followed by peptide affinity purification.
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
Supplied in PBS with 0.09% (W/V) sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
This gene encodes coagulation factor XIII B subunit.
Coagulation factor XIII is the last zymogen to become activated in
the blood coagulation cascade. Plasma factor XIII is a
heterotetramer composed of 2 A subunits and 2 B subunits. The A
subunits have catalytic function, and the B subunits do not have
enzymatic activity and may serve as a plasma carrier molecules.
Platelet factor XIII is comprised only of 2 A subunits, which are
identical to those of plasma origin. Upon activation by the
cleavage of the activation peptide by thrombin and in the presence
of calcium ion, the plasma factor XIII dissociates its B subunits
and yields the same active enzyme, factor XIIIa, as platelet factor
XIII. This enzyme acts as a transglutaminase to catalyze the
formation of gamma-glutamyl-epsilon-lysine crosslinking between
fibrin molecules, thus stabilizing the fibrin clot. Factor XIII
deficiency is classified into two categories: type I deficiency,
characterized by the lack of both the A and B subunits; and type II
deficiency, characterized by the lack of the A subunit alone.
These defects can result in a lifelong bleeding tendency, defective
wound healing, and habitual abortion.
Accession #:
P05160
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