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折扣/货期| 货号：AG-40B-0278-C050 | 规格：50 ug | 目录价：￥4800 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Famsin (mouse) (rec.) (His)
别名:
Uncharacterized Protein C17orf78 Homolog; Gm11437
产品描述:
Famsin, coded by the gene Gm11437, promotes metabolic adaptations to fasting. Famsin is cleaved by furin from a single-pass transmembrane protein, Gm11437, during fasting. Famsin is primarily expressed by enterocytes and enteroendocrine cells in the intestine. Famsin binds to the olfactory G-protein-coupled receptor OLFR796 to activate intracellular calcium mobilization and to induce glucagon secretion. This famsin-OLFR796-glucagon signaling axis promotes gluconeogenesis and ketogenesis in the liver for energy mobilization. OLFR796, which is highly expressed in olfactory epithelium (OE) and olfactory bulb (OB) and in intestinal crypts and islets, promotes torpor for energy conservation and fasting-induced enhancement of energy mobilization in mice, thus enhancing mouse metabolic adaptations to fasting. Deficiency of famsin signaling in humans and mice attenuates glucagon secretion and reduces blood glucose levels, showing the importance of gut-islet-liver endocrine crosstalk, mediated by a famsin-glucagon axis, in glucose homeostasis.
宿主来源:
CHO cells
产品浓度:
After reconstitution: 1mg/ml
保存温度:
+4°C
运输温度:
BI
预期分子量:
~35kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
内毒素水平:
<0.01EU/µg protein (LAL test).
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