Fc (human):Grancalcin (human) (rec.)-其他重组蛋白-深圳欣博盛生物科技有限公司

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Fc (human):Grancalcin (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0242-C050

规格：50 ug

目录价：￥4800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Fc (human):Grancalcin (human) (rec.)

别名:

GCA; GCL

产品描述:

Grancalcin is a member of a new family of proteins named penta-EF-hand (PEF), which contains five repetitive EF hand motifs. PEF proteins form a unique group including calpain, sorcin, grancalcin, ALG-2 (apoptosis-linked gene-2 protein) and peflin. The penta-EF hand members are Ca2+-binding proteins implicated in regulating cell migration, apoptosis and the mobilization of immune cells. Senescent cells accumulate in the bone marrow and secrete factors, termed senescence-associated secretory phenotype (SASP), that can promote skeletal aging. Recently, senescent neutrophils and macrophages in the bone marrow were shown to be critical cell types during skeletal aging releasing Grancalcin (GCA) to promote such aging. Grancalcin seems to act by competitively binding to and inactivating PlexinB2 functions in bone marrow stromal cells (BMSCs) leading to repression of osteogenesis and increase of adipogenesis. Increased Grancalcin expression in immune cells (bone marrow macrophages and in neutrophils) is due to higher endotoxin levels observed during aging.

宿主来源:

HEK 293 cells

产品浓度:

1mg/ml after reconstitution.

保存温度:

+4°C

运输温度:

预期分子量:

~65kDa (SDS-PAGE)

产品形式:

solid

存储溶液: