FE65 Antibody-多抗-深圳欣博盛生物科技有限公司

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FE65 Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：R31784

规格：100 ug

目录价：￥6488.05

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

FE65 Antibody

产品描述:

APBB1/RIR/FE65 is a transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). encoding different isoforms have been described for this gene.

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

WB, IHC-P

同种型:

Rabbit IgG

免疫原:

Amino acids ALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGE of human FE65 were used as the immunogen for the FE65 antibody.

克隆性:

Polyclonal (rabbit origin)

纯化方式:

Antigen affinity

保存温度:

After reconstitution, the FE65 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

产品形式:

Antigen affinity purified

存储溶液:

0.5mg/ml if reconstituted with 0.2ml sterile DI water

产地:

美国

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