FGFR1 Antibody-单抗-深圳欣博盛生物科技有限公司

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FGFR1 Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：F53032-0.08ML	规格：0.08 ml	目录价：￥2962
货号：F53032-0.4ML	规格：0.4 ml	目录价：￥6344

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

FGFR1 Antibody

产品描述:

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

反应种属:

Human

宿主来源:

Mouse

实验应用:

WB, IF, IHC-P, ELISA (immunogen)

同种型:

Mouse IgG1, kappa

免疫原:

This FGFR1 antibody was produced from a mouse immunized with a KLH conjugated synthetic peptide between 806-842 amino acids from the C-terminal region of human FGFR1.

克隆性:

Monoclonal (mouse origin)

克隆号:

1440CT772.50.23

纯化方式:

Purified

保存温度:

Aliquot the FGFR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

产品形式:

Purified

存储溶液:

In 1X PBS, pH 7.4, with 0.09% sodium azide