FOXP1 Antibody-多抗-深圳欣博盛生物科技有限公司

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FOXP1 Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：RQ5814

规格：100 ug

目录价：￥6488.05

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

FOXP1 Antibody

产品描述:

FOXP1 (forkhead box P1) is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors. This gene belongs to subfamily P of the forkhead box(FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region(3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. It was shown that the embryonic stem cell(ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs(2).

反应种属:

Human, Mouse, Rat, Monkey

宿主来源:

Rabbit

实验应用:

WB, IHC-P

同种型:

Rabbit IgG

免疫原:

Amino acids DFDHDRDYEDEPVNEDME from the human protein were used as the immunogen for the FOXP1 antibody.

克隆性:

Polyclonal (rabbit origin)

纯化方式:

Affinity purified

保存温度:

After reconstitution, the FOXP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

产品形式:

Antigen affinity purified

存储溶液:

0.5mg/ml if reconstituted with 0.2ml sterile DI water

产地:

美国

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