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折扣/货期| 货号：F53804-0.05ML | 规格：0.05 ml | 目录价：￥2962 |
| 货号：F53804-0.2ML | 规格：0.2 ml | 目录价：￥6344 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
FZR1 Antibody
产品描述:
Fizzy related protein 1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
反应种属:
Human
宿主来源:
Mouse
实验应用:
WB
同种型:
Mouse IgG1, kappa
免疫原:
Human recombinant protein corresponding to amino acids 1-496 was used as the immunogen for this FZR1 antibody.
克隆性:
Monoclonal (mouse origin)
克隆号:
1621CT637.76.67
纯化方式:
Protein G affinity chromatography
保存温度:
Aliquot the FZR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Purified
存储溶液:
In 1X PBS, pH 7.4, with 0.09% sodium azide
产地:
美国
促销活动
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