GCN2 Antibody-多抗-深圳欣博盛生物科技有限公司

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GCN2 Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：R31137

规格：100 ug

目录价：￥6488.05

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GCN2 Antibody

产品描述:

Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4, also called GCN2 (General control nonderepressible 2), is an enzyme that in humans is encoded by the EIF2AK4 gene. It belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses. Hartz(2005) mapped the gene to chromosome 15q15.1 based on an alignment of the protein sequence with the genomic sequence. Berlanga et al.(1999) demonstrated that GCN2 immunopurified from mouse liver extracts could phosphorylate rabbit Eif2 in vitro. Serum starvation increased the level of phosphorylated EIF2-alpha more than 2-fold in human embryonic kidney cells transfected with mouse Eif2ak4. Costa-Mattioli et al.(2005) reported a unique feature of hippocampal slices from GCN2-null mice: in CA1, a single 100-Hz train induced a strong and sustained long-term potentiation(late LTP or L-LTP), which was dependent on transcription and translation.

反应种属:

Mouse, Rat

宿主来源:

Rabbit

实验应用:

同种型:

Rabbit IgG

免疫原:

An amino acid sequence from the middle region of mouse GCN2 (ATDHLAFTAEGKQDDQAGD) was used as the immunogen for this GCN2 antibody.

克隆性:

Polyclonal (rabbit origin)

纯化方式:

Antigen affinity

保存温度:

After reconstitution, the GCN2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

产品形式:

Antigen affinity purified

存储溶液:

0.5mg/ml if reconstituted with 0.2ml sterile DI water

产地:

美国

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