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折扣/货期| 货号：42538-1 mg | 规格：1 mg | 目录价：￥428.8 |
| 货号：42538-10 mg | 规格：10 mg | 目录价：￥3216 |
| 货号：42538-25 mg | 规格：25 mg | 目录价：￥5882.6 |
| 货号：42538-5 mg | 规格：5 mg | 目录价：￥1822.4 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
GNF-4877
产品描述:
A Dyrk1a and Gsk3ß inhibitor (IC50s = 6 and 16 nM, respectively, for the mouse enzymes); selective for Dyrk1a and Gsk3ß over a panel of 57 kinases but does inhibit 10 other kinases at 1 µM; increases the proliferation of R7T1 mouse pancreatic ß-cells and primary human pancreatic ß-cells (EC50s = 0.66 and 0.54 µM, respectively); increases the number of islet and ß-cells and the levels of total DNA and ATP in primary human islet cells at 2 µM; increases the proliferation of transplanted primary human islet cells and decreases the levels of blood glucose in mice at 50 mg/kg twice per day; reduces the levels of blood glucose in an OGTT in a transgenic RIP-DTA mouse model of type I diabetes at 50 mg/kg twice per day; increases the mass of, and levels of insulin in, pancreatic ß-cells in the same mice
保存温度:
-20
运输温度:
-20
预期分子量:
494.518323
产品形式:
A solid
有效期:
1460
纯度:
≥98%
CAS号:
2041073-22-5
分子式:
C25H27FN6O4
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