GSK 199 (hydrochloride)-抑制剂-深圳欣博盛生物科技有限公司

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GSK 199 (hydrochloride)

品牌：Cayman

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说明书

折扣/货期

货号：17489-1 mg	规格：1 mg	目录价：￥1112
货号：17489-10 mg	规格：10 mg	目录价：￥4985
货号：17489-25 mg	规格：25 mg	目录价：￥11055
货号：17489-5 mg	规格：5 mg	目录价：￥3323

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GSK 199 (hydrochloride)

产品描述:

A PAD4 inhibitor (IC50 = 200 nM in the absence of calcium); selectively inhibits the production of citrulline by PAD4 over PAD1, PAD2, and PAD3 in kinetic assays; prevents ionomycin-induced histone H3 citrullination and NET formation in isolated mouse peripheral blood neutrophils at 10 µM; reduces HCoV-OC43 replication in infected MRC-5 cells (IC50 = 0.6 µM); reduces complement C3 deposition in the synovium and cartilage at 10 and 30 mg/kg and reduces disease severity at 30 mg/kg in a mouse model of collagen-induced arthritis; reduces plasma NET levels and brain infarct volume, as well as improves neurological outcomes, in a mouse model of tMCAO-induced ischemic stroke at 30 mg/kg

保存温度:

-20

运输温度:

-20

预期分子量:

432.54

产品形式:

A crystalline solid

纯度:

≥98%

CAS号:

1549811-53-1