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折扣/货期| 货号：27305-1 mg | 规格：1 mg | 目录价：￥482 |
| 货号：27305-10 mg | 规格：10 mg | 目录价：￥2935 |
| 货号：27305-25 mg | 规格：25 mg | 目录价：￥5065 |
| 货号：27305-5 mg | 规格：5 mg | 目录价：￥1715 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
GSK3326595
产品描述:
A PRMT5 inhibitor; inhibits methylation of peptides derived from histones H4 and H2A, SmD3, FUBP1, and HNRNPH1 by the PRMT5/MEP50 complex (IC50s = 5.9-19.7 nM); more than 4,000-fold selective for PRMT5/MEP50 over a panel of 20 methyltransferases; induces alternative splicing of MDM4 in Z-138, MCF-7, JM1, and DOHH-2 cells at 200 nM; increases p53 and p21 protein levels in Z-138 cells in a concentration-dependent manner; inhibits growth and SDMA methylation in several lymphoma and breast cancer cell lines; reduces tumor growth in a Z-138 mouse xenograft model at 25, 50, and 100 mg/kg twice per day
保存温度:
-20
运输温度:
-20
预期分子量:
452.6
产品形式:
A solid
纯度:
≥98%
CAS号:
1616392-22-3
分子式:
C24H32N6O3
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