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折扣/货期| 货号：28759-1 mg | 规格：1 mg | 目录价：￥844 |
| 货号：28759-10 mg | 规格：10 mg | 目录价：￥3672 |
| 货号：28759-5 mg | 规格：5 mg | 目录价：￥2050 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
GW843682X
产品描述:
A reversible, cell-permeable PLK inhibitor; selectively inhibits Plk1 and Plk3 (IC50s = 2.2 and 9.1 nM, respectively) over more than 30 other kinases in a cell-free assay; inhibits Plk1 activity in vitro in HeLa cells using a chimeric Plk1 reporter assay (IC50 = 0.14 μM); inhibits growth in nine cancer cell lines in a panel (IC50s = 0.11-0.7 μM) but not of PC3 human prostate cancer cells (IC50 = 6.82 μM) or non-cancerous human diploid fibroblasts (HDFs; IC50 = 6.14 µM); inhibits growth of MES-SA human uterine sarcoma cells, as well as of the drug-resistant, P-glycoprotein-expressing MES-SA/Dx5 subline (IC50s = 0.21 and 0.21 μM, respectively); inhibits the growth of patient-derived leukemia cells (IC50s = 2/M cell cycle arrest and apoptosis of H460 human lung and PALL-2 and MOLM13 human leukemia cancer cells in a concentration-dependent manner
保存温度:
-20
运输温度:
-20
预期分子量:
477.457349
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
660868-91-7
分子式:
C22H18F3N3O4S
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