H2AK119ub1 Recombinant Nucleosome, Biotinylated-突变/修饰核小体-深圳欣博盛生物科技有限公司

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H2AK119ub1 Recombinant Nucleosome, Biotinylated

品牌：EpiCypher

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说明书

折扣/货期

货号：16-0395

规格：25 µg

目录价：￥6300

产品详情

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产品名称:

H2AK119ub1 Recombinant Nucleosome, Biotinylated

产品描述:

Histone ubiquitination is a post-translational modification (PTM) wherein ubiquitin is added to a lysine residue of a histone protein. In combination with other PTMs, histone ubiquitination constitutes the “histone code,” acting as a language read by proteins to regulate chromatin structure and gene expression. Ubiquitin is added through the sequential actions of E1 activating, E2 conjugating, and E3 ligating enzymes and is removed by deubiquitinating enzymes (DUBs). Histone ubiquitination plays an integral role in DNA damage response and has been implicated in transcriptional regulation and DNA replication [1]. Recombinant nucleosomes containing ubiquitinated histones are useful to study the biological functions of histone ubiquitination. H2AK119ub1 (histone H2A lysine 119 ubiquitination) Recombinant Nucleosome, Biotinylated consists of 147 base pairs of 601 sequence DNA [2] wrapped around an octamer of core histone proteins (two each of H2A, H2B, H3.1, and H4) to form a nucleosome, the basic repeating unit of chromatin. The DNA contains a 5’ biotin-TEG group. H2AK119ub1 nucleosome contains ubiquitinated lysine at position 119 on histone H2A. H2AK119 is ubiquitinated by E3 ligase RING1A/B, subunits of the polycomb repressive complex 1 (PRC1), in vivo. H2AK119ub1 is an abundant histone mark that plays a role in transcriptional regulation [1].

宿主来源:

Human

表达系统:

E. coli & synthetic DNA

保存温度:

Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid freeze/thaws.

运输温度:

Dry ice.

产地:

美国

生产商:

EpiCypher