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折扣/货期| 货号：42106-1 mg | 规格：1 mg | 目录价：￥3337 |
| 货号：42106-10 mg | 规格：10 mg | 目录价：￥14043 |
| 货号：42106-5 mg | 规格：5 mg | 目录价：￥8777 |
| 货号：42106-500 µg | 规格：500 µg | 目录价：￥1755 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
H3B-8800
产品描述:
An inhibitor of the SF3B complex; binds to SF3B complexes containing wild-type SF3B (IC50 = 1.4 nM) or various SF3B mutations (IC50s = 0.3-1.8 nM); inhibits SF3B1-induced splicing of canonical and aberrant pre-mRNA junctions in HEK293T nuclear extracts overexpressing SF3B1K700E; selectively inhibits the growth of, and induces apoptosis in, Panc 05.04 pancreatic cancer cells expressing mutant SF3B over Panc 10.05, HAPF-II, and CFPAC-1 pancreatic cancer cells expressing wild-type SF3B in a concentration-dependent manner; reduces tumor growth in a K562 mouse xenograft model using K562 cells expressing wild-type SF3B1 at 8 mg/kg and K562 cells expressing SF3B1K700E at 2, 4, or 8 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
555.70562
产品形式:
A solid
纯度:
≥98%
CAS号:
1825302-42-8
分子式:
C31H45N3O6
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