HDAC3 Antibody-多抗-深圳欣博盛生物科技有限公司

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HDAC3 Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：RQ5284

规格：100 ug

目录价：￥6488.05

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

HDAC3 Antibody

产品描述:

HDAC3 (HISTONE DEACETYLASE 3) is a member of the histone deacetylase/acuc/apha family of proteins that is an enzyme that in humans is encoded by the HDAC3 gene. The HDAC3 gene is mapped to 5q31.3. HDAC3 has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. The protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. And this gene is regarded as a potential tumor suppressor gene. HDAC3 has an open reading frame of 428 amino acids and shares 53% amino acid identity with HDAC1 and 52% with HDAC2. The catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor NCOR2. All experimental conditions leading to the suppression of HDAC4 binding to NCOR2 and to HDAC3 resulted in loss of enzymatic activity associated with HDAC4. HDAC3 recruitment to the genome displays a circadian rhythm in mouse liver.

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

WB, FACS, Direct ELISA

同种型:

Rabbit IgG

免疫原:

Amino acids M1-I428 from the human protein were used as the immunogen for the HDAC3 antibody.

克隆性:

Polyclonal (rabbit origin)