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折扣/货期| 货号：CHI-HF-21035-C025 | 规格：25 ug | 目录价：￥3360 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IL-35 (human):Fc (human) (rec.)
别名:
Interleukin-35
产品描述:
Interleukin-35 (IL-35) is a novel IL-12 family cytokine produced by regulatory T cells (Treg) but not by resting or activated effector T cells (Teff). IL-35 is a heterodimeric protein composed of EBI3 (Epstein-Barr-Virus-induced gene 3) and IL-12a (p35). EBI3 is a downstream target of Foxp3, a transcription factor required for Treg-cell development and function, and thus Treg-cell restriction of IL35 occurs. Regulatory T cells are essential for maintaining self tolerance and preventing autoimmunity, and IL-35 is identified as a molecule that mediates the immune suppression function of Treg-cell. As an inhibitory cytokine, IL-35 induces proliferation of Treg-cell populations but suppresses Th17 cell development. Studies in mice show the absence of either IL-35 chain from Treg-cell reduces the cells' ability to suppress inflammation using an experimental model for inflammatory bowel disease. IL-35 is suggested as a potential target of immunotherapy.
宿主来源:
CHO cells
保存温度:
+4°C
运输温度:
BI
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
产地:
瑞士
纯度:
>98% (SDS-PAGE)
生物活性:
Bioactivity was measured in a cell proliferation assay using anti-CD3 activated human peripheral mononuclear cells.
内毒素水平:
<0.06EU/µg protein (LAL test; Lonza).
促销活动
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