INCB 086550-其他小分子化合物-深圳欣博盛生物科技有限公司

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INCB 086550

品牌：Cayman

官网链接

说明书

折扣/货期

货号：38781-1 mg	规格：1 mg	目录价：￥1595
货号：38781-5 mg	规格：5 mg	目录价：￥7048
货号：38781-500 µg	规格：500 µg	目录价：￥844

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

INCB 086550

产品描述:

A PD-1/PD-L1 interaction inhibitor; inhibits PD-1 binding to PD-L1 in CHO cells expressing human PD-L1 (EC50 = 13.2 nM); induces dimerization and internalization of PD-L1 in CHO cells expressing human PD-L1 at 1 µM; decreases the levels of unoccupied cell-surface PD-L1 in mouse MBT-2 bladder cancer cells expressing human PD-L1 at low, medium, or high levels (EC50s = 3.7, 0.4, and 0.1 nM, respectively); prevents PD-1-induced recruitment of SHP in a reporter assay using Jurkat T cells co-cultured with U2OS cells expressing human PD-L1 (IC50 = 6.3 nM); induces activation of NFAT in a reporter assay using Jurkat T cells co-cultured with CHO-K1 cells (IC50 = 21.4 nM); reduces tumor volume and intratumoral cell-surface levels of PD-L1, as well as increases CD8+ T cell tumor infiltration, in a MC-38 murine allograft model of colon carcinoma overexpressing human PD-L1 at 20 or 200 mg/kg per day

保存温度:

-20

运输温度:

-20

预期分子量:

693.79314

产品形式:

A solid

纯度:

≥98%

CAS号:

2230911-59-6