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折扣/货期| 货号：AG-CR1-3581-M005 | 规格：5 mg | 目录价：￥1080 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IWR-1-endo
别名:
4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
产品描述:
Potent and reversible cell permeable Wnt pathway signaling inhibitor [1, 2, 4, 5]. Inhibits Wnt-induced accumulation of beta-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3beta. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3beta. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay) [3, 6].
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
409.4
产品形式:
solid
产地:
瑞士
纯度:
>98%
CAS号:
1127442-82-3
分子式:
C25H19N3O3
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