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折扣/货期| 货号：27650-10 mg | 规格：10 mg | 目录价：￥2117 |
| 货号：27650-100 mg | 规格：100 mg | 目录价：￥12355 |
| 货号：27650-5 mg | 规格：5 mg | 目录价：￥1273 |
| 货号：27650-50 mg | 规格：50 mg | 目录价：￥6834 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
JNJ-38877605
产品描述:
An ATP-competitive inhibitor of Met kinase (IC50 = 4 nM); at least 600-fold selective for Met in a panel of ~250 tyrosine and serine-threonine kinases; inhibits the growth of cancer cell lines with MET gene amplification (IC50s = 11-50 nM) but has no effect on the growth of control cells with normal MET gene copy number or no MET expression; sensitizes tumors to radiotherapy in U251 glioma and MDA-MB-231 breast cancer mouse xenograft models and increases apoptosis in irradiated tumors in the MDA-MB-231 mouse xenograft model at 50 mg/kgp; reduces tumor size by 6-fold and the number of blood vessels in tumors by 80% in an RU-P melanoma mouse xenograft model at 20 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
377.350506
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
943540-75-8
分子式:
C19H13F2N7
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