L-778,123 (hydrochloride)-抑制剂-深圳欣博盛生物科技有限公司

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L-778,123 (hydrochloride)

品牌：Cayman

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说明书

折扣/货期

货号：22940-10 mg	规格：10 mg	目录价：￥2439
货号：22940-25 mg	规格：25 mg	目录价：￥5682
货号：22940-5 mg	规格：5 mg	目录价：￥1434
货号：22940-50 mg	规格：50 mg	目录价：￥9916

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

L-778,123 (hydrochloride)

产品描述:

A dual inhibitor of FTase and GGTase I (IC50s = 2 and 98 nM, respectively); inhibits prenylation of FTase and GGTase I substrates HDJ2 and RAP1A in PSN-1 pancreatic tumor cells (EC50s = 92 and 6,760 nM, respectively); inhibits prenylation of the oncogenic protein KI-RAS in PSN-1 cells in a concentration-dependent manner; reduces HDJ2 and RAP1A prenylation ex vivo in dog PBMCs when administered at a dose of 35-50 mg/kg per day; has no effect on KI-RAS prenylation in patient-derived PBMCs; inhibits lectin-induced expression of the T cell activation markers CD71 and CD25 on human PMBCs (IC50s = 6.48 and 84.1 μM, respectively); inhibits IL-2-induced proliferation of CTLL-2 cells (IC50 = 0.81 μM)

保存温度:

-20

运输温度:

-20

预期分子量:

442.3

产品形式:

A crystalline solid

纯度:

≥98%

CAS号:

253863-00-2