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折扣/货期| 货号：36414-10 mg | 规格：10 mg | 目录价：￥590 |
| 货号：36414-100 mg | 规格：100 mg | 目录价：￥2064 |
| 货号：36414-25 mg | 规格：25 mg | 目录价：￥1032 |
| 货号：36414-50 mg | 规格：50 mg | 目录价：￥1474 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
LEE011 (succinate)
别名:
NVP-LEE011|Ribociclib
产品描述:
An inhibitor of Cdk4/6 (IC50s = 0.53 and 2.3 nM, respectively); selective for Cdk4/6 over Cdk1, Cdk2, Cdk5, Cdk7, and Cdk9 (IC50s = >1,400, >2,500, >2,000, >2,000, and 190 nM, respectively); reduces MCF-7 and T47D cell proliferation (IC50s = 200 and 260 nM, respectively); induces cell death in C666-1 and NPC/HK1 cells (IC50s = 12.25 and 5.07 µM, respectively) and cell cycle arrest in the G0/G1 phase in the same cells at 10 µM; reduces tumor growth in combination with alpelisib in two PDX mouse models of nasopharyngeal carcinoma at 200 mg/kg every two weeks
保存温度:
-20
运输温度:
-20
预期分子量:
434.53762
产品形式:
A solid
纯度:
≥98%
CAS号:
1374639-75-4
分子式:
C23H30N8O • C4H6O4
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