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折扣/货期| 货号：44231-10 mg | 规格：10 mg | 目录价：￥2144 |
| 货号：44231-25 mg | 规格：25 mg | 目录价：￥3457.2 |
| 货号：44231-5 mg | 规格：5 mg | 目录价：￥1259.6 |
| 货号：44231-50 mg | 规格：50 mg | 目录价：￥6271.2 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Lerociclib
别名:
G1T38
产品描述:
A dual inhibitor of Cdk4 and Cdk6 (IC50s = 1 and 2 nM for Cdk4/cyclin D1 and Cdk6/cyclin D3, respectively); selective for Cdk4 and Cdk6 over seven related Cdks, including Cdk9/cyclin T, Cdk5/p25, and Cdk1/cyclin B1 (IC50s = 28, 1,200, and 2,400 nM, respectively); induces cell cycle arrest at the G1 phase in WM266-4 cells (EC50 = ~20 nM); selectively inhibits the proliferation of a variety of Rb-expressing cancer cells over non-Rb-expressing cancer cells (EC50s = 23-784 and 2,691->10,000 nM, respectively); reduces intratumoral pRb levels in an MCF-7 mouse xenograft model at a single dose of 100 mg/kg; inhibits tumor growth in an MCF-7 mouse xenograft model at 10-100 mg/kg in the diet for 28 days
保存温度:
-20
运输温度:
-20
预期分子量:
474.613
产品形式:
A solid
有效期:
1460
纯度:
≥98%
CAS号:
1628256-23-4
分子式:
C26H34N8O
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