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折扣/货期| 货号：AG-40B-0093-3010 | 规格：3 x 10 ug | 目录价：￥3360 |
| 货号：AG-40B-0093-C010 | 规格：10 ug | 目录价：￥1680 |
| 货号：AG-40B-0093-C100 | 规格：100 ug | 目录价：￥10080 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
LIF (human) (rec.)
别名:
Leukemia Inhibitory Factor; Differentiation-stimulating Factor; D Factor; Melanoma-derived LPL Inhibitor
产品描述:
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities also include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation and the stimulation of acute-phase protein synthesis in hepatocytes. LIF activates JAK & STAT signaling in human embryonic stem (ES) cells, but this pathway does not maintain pluripotency in these cells, which instead rely on FGF2-mediated ERK signaling. By contrast, mouse ES cells can be maintained by LIF-mediated JAK & STAT signaling. LIF binds to a high affinity heterodimeric receptor complex consisting of two proteins: LIF-R alpha that binds LIF with low affinity and the 130kDa (gp130) subunit that by itself does not bind LIF, but is required for high affinity binding of LIF.
宿主来源:
E. coli
靶标/特异性:
Mouse and human embryonic stem cells.
产品浓度:
AG-40B-0093-C010/AG-40B-0093-3010: 0.1mg/ml after reconstitution.AG-40B-0093-C100: 1mg/ml after reconstitution.
保存温度:
+4°C
运输温度:
BI
预期分子量:
~46kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Maintains pluripotency of mouse and human embryonic stem cells. The LIF (GST-tagged) from AdipoGen has the same activity as cleaved LIF.
内毒素水平:
<0.05EU/µg purified protein (LAL test; Lonza).
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