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折扣/货期| 货号：AG-CR1-3618-M010 | 规格：10 mg | 目录价：￥480 |
| 货号：AG-CR1-3618-M050 | 规格：50 mg | 目录价：￥1080 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Linagliptin
别名:
8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione; BI-1356
产品描述:
Antidiabetic agent. Highly potent and selective competitive inhibitor of dipeptidyl-peptidase 4 (DPP4; DPP IV; CD26), an enzyme that degrades, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Prevents the inactivation of endogenous GLP-1 and GIP. Shown to restore beta cell function and survival in human isolated islets through GLP-1 stabilization. Improves insulin sensitivity. Anti-inflammatory compound. DPP4 is a cell surface aminopeptidase that exerts diverse biological activities, such as protease activity, association with adenosine deaminase, interaction with the extracellular matrix, regulation of intracellular signal transduction coupled with the control of cell migration and proliferation, and in addition cell surface co-receptor activity mediating viral entry. DPP4 is a viral receptor of human coronaviruses and therefore is investigated as a potential target for SARS-CoV-2 infections.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
472.5
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
668270-12-0
分子式:
C25H28N8O2
溶解度:
Soluble in DMSO (5mg/ml), ethanol or methanol. Slightly soluble in water (~1mg/ml).
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