Lopinavir-抑制剂-深圳欣博盛生物科技有限公司

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Lopinavir

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3715-M025	规格：25 mg	目录价：￥360
货号：AG-CR1-3715-M100	规格：100 mg	目录价：￥960
货号：AG-CR1-3715-M250	规格：250 mg	目录价：￥1920

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Lopinavir

别名:

A-157378.0; ABT-378; Aluviran

产品描述:

The antiviral agent Lopinavir is a potent inhibitor of HIV-1 protease (Ki=1.3pM for wild-type enzyme) and has been shown to block the replication of clinical isolates of HIV (EC50s=5-52nM). Lopinavir is an antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). Lopinavir/ritonavir inhibits the HIV protease enzyme by forming an inhibitor-enzyme complex thereby preventing cleavage of the gag-pol polyproteins. Immature, non- infectious viral particles are subsequently produced. Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24). HIV-PIs block prelamin A processing by directly affecting the enzymatic activity of ZMPSTE24 and in this way they may contribute to lipodystrophy in individuals undergoing HIV-PI treatment. It also has been shown to inhibit meningioma cell proliferation, induce apoptosis on lymphoma cells and inhibit insulin signaling. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the coronavirus endopeptidase C30 (CEP_C30) of SARS-CoV-2. A initial randomized trial study was not successful.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

628.8

产品形式:

solid

产地:

瑞士

纯度:

>98% (1H-NMR)