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折扣/货期| 货号：AG-CR1-3715-M025 | 规格：25 mg | 目录价：￥360 |
| 货号：AG-CR1-3715-M100 | 规格：100 mg | 目录价：￥1080 |
| 货号：AG-CR1-3715-M250 | 规格：250 mg | 目录价：￥2040 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Lopinavir
别名:
A-157378.0; ABT-378; Aluviran
产品描述:
The antiviral agent Lopinavir is a potent inhibitor of HIV-1 protease (Ki=1.3pM for wild-type enzyme) and has been shown to block the replication of clinical isolates of HIV (EC50s=5-52nM). Lopinavir is an antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). Lopinavir/ritonavir inhibits the HIV protease enzyme by forming an inhibitor-enzyme complex thereby preventing cleavage of the gag-pol polyproteins. Immature, non- infectious viral particles are subsequently produced. Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24). HIV-PIs block prelamin A processing by directly affecting the enzymatic activity of ZMPSTE24 and in this way they may contribute to lipodystrophy in individuals undergoing HIV-PI treatment. It also has been shown to inhibit meningioma cell proliferation, induce apoptosis on lymphoma cells and inhibit insulin signaling. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the coronavirus endopeptidase C30 (CEP_C30) of SARS-CoV-2. A initial randomized trial study was not successful.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
628.8
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (1H-NMR)
CAS号:
192725-17-0
分子式:
C37H48N4O5
溶解度:
Soluble in ethanol (20mg/ml), DMSO (15mg/ml) or dimtheylformamide (15mg/ml).
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