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折扣/货期| 货号：8223-0.02 mg | 规格：0.02 mg | 目录价：￥1345.5 |
| 货号：8223-0.1 mg | 规格：0.1 mg | 目录价：￥6084 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
LSD1 Antibody
别名:
Lysine-specific histone demethylase, amine oxidase flavin containing domain protein 2, AOF2
反应种属:
Human,Mouse,Rat
宿主来源:
Rabbit
实验应用:
ELISA,WB,IHC-P
靶标/特异性:
At least two isoforms of LSD1 are known to exist; this antibody detects both.
同种型:
IgG
克隆性:
Polyclonal
纯化方式:
LSD1 antibody is affinity chromatography purified via peptide column.
偶联:
Unconjugated
产品浓度:
1 mg/mL
保存温度:
LSD1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
LSD1 antibody is supplied in PBS containing 0.02% sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction (1). Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription (2). LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation (3,4). Experiments have shown that CoREST, a SANT domain-containing corepressor (5) acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein (6), inhibits CoREST/LSD1 activity in vitro (3). LSD1-mediated histone demethylation thus may have significant effects on gene expression.
Accession #:
NP_001009999
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