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折扣/货期| 货号：AG-40B-0274-C050 | 规格：50 ug | 目录价：￥2160 |
| 货号：AG-40B-0274-3050 | 规格：3 x 50 ug | 目录价：￥4320 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
LTbetaR (mouse):Fc (human) (rec.)
别名:
Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3; Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor
产品描述:
Lymphotoxin beta receptor (LTbetaR) belongs to the tumor necrosis factor receptor superfamily (TNFR) and is a key regulator of lymphoid organogenesis and inflammation. LTbetaR is primarily expressed by epithelial cells, dendritic cells (DCs), stromal cells and macrophages. LTbetaR interacts with two ligands: membrane heterotrimeric lymphotoxin LTalpha1beta2 (LT) and homotrimeric LIGHT, both expressed predominantly by activated lymphoid cells. LTbetaR signaling can activate both canonical and alternative NF-kB signaling to induce various proinflammatory chemokines and cytokines and promote apoptosis via TRAF3 and TRAF5. LTbetaR also plays a role in the development of lymphoid organs. LTbetaR (mouse):Fc treatment partially impairs the structure of secondary lymphoid organs and shows therapeutic efficacy in various models of inflammatory diseases.
宿主来源:
HEK 293 cells. Produced using animal component-free medium.
靶标/特异性:
Binds to mouse and human LTalpha1beta2 (Lymphotoxin beta) and LIGHT (TNFsf14).
产品浓度:
1mg/ml after reconstitution.
保存温度:
+4°C
运输温度:
BI
预期分子量:
~60kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
内毒素水平:
<0.01EU/µg purified protein (LAL test).
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