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折扣/货期| 货号：37711-1 mg | 规格：1 mg | 目录价：￥523 |
| 货号：37711-10 mg | 规格：10 mg | 目录价：￥2586 |
| 货号：37711-5 mg | 规格：5 mg | 目录价：￥1554 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Lucitanib (hydrochloride)
别名:
AL 3810|E-3810
产品描述:
A dual inhibitor of VEGFR and FGFR; inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50s = 7, 25, and 10 nM, respectively) and FGFR1 and FGFR2 (IC50s = 17.5 and 82.5 nM, respectively); selective for VEGFR1-3 and FGFR1-2 over FGFR3 and FGFR4 (IC50s = 237.5 and >1,000 nM, respectively), as well c-Kit, PDGFRα, and PDGFRβ (IC50s = 456, 175, and 525 nM, respectively), but does inhibit FMS (IC50 = 5 nM); inhibits VEGF- or bFGF-induced HUVEC proliferation (IC50s = 40 and 50 nM, respectively) but inhibits the proliferation of A2780, A498, and SN12KI cancer cells only at higher concentrations (IC50s = 27.7, 19.6, and 12.79 µM, respectively); reduces tumor growth in various mouse xenograft models in a dose-dependent manner; completely inhibits bFGF-induced angiogenesis in a Matrigel™ plug assay in mice at 20 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
443.49452
产品形式:
A crystalline solid
纯度:
≥95%
CAS号:
2108875-91-6
分子式:
C26H25N3O4 • 2HCl
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