官网链接
折扣/货期| 货号：41169-1 mg | 规格：1 mg | 目录价：￥670 |
| 货号：41169-10 mg | 规格：10 mg | 目录价：￥3323 |
| 货号：41169-25 mg | 规格：25 mg | 目录价：￥6633 |
| 货号：41169-5 mg | 规格：5 mg | 目录价：￥2157 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
M4K2234
产品描述:
An ALK1 and ALK2 inhibitor (IC50s = 7 and 14 nM, respectively); selective for ALK1 and ALK2 over ALK3, -4, -5, and -6 (IC50s = 168, 1,660, 1,950, and 88 nM, respectively), as well as 30 additional kinases at 1 µM, but does inhibit TNIK (IC50 = 41 nM); inhibits ALK2 containing the gain-of-function mutations ALK2G328V, ALK2R206H, and ALK2R258G (IC50s = 3, 6, and 6 nM, respectively); reduces BMP7-induced increases in SMAD1/5/8 phosphorylation in vitro at 100-10,000 nM; reduces growth of patient-derived SU-DIPG-XXI and HSJD-DIPG-007 cells containing the respective mutations ALK2G328W and ALK2R206H (GI50s = 0.04 and 4.3 µM, respectively
保存温度:
-20
运输温度:
-20
预期分子量:
462.559203
产品形式:
A solid
纯度:
≥98%
CAS号:
2421141-51-5
分子式:
C27H31FN4O2
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询