MD2-IN-1-其他小分子化合物-深圳欣博盛生物科技有限公司

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MD2-IN-1

品牌：Cayman

官网链接

说明书

折扣/货期

货号：38323-1 mg	规格：1 mg	目录价：￥523
货号：38323-10 mg	规格：10 mg	目录价：￥3886
货号：38323-25 mg	规格：25 mg	目录价：￥6459
货号：38323-5 mg	规格：5 mg	目录价：￥2332

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MD2-IN-1

别名:

Myeloid Differentiation 2 Inhibitor 1

产品描述:

A chalcone derivative and an inhibitor of the MD-2-LPS interaction; inhibits the interaction between MD-2 and LPS in a cell-free assay at 0.1 µM; inhibits LPS-induced increases in the levels of Tnf-α and Il-6 secreted from isolated and washed MPMs (IC50s = 4.27 and 2.09 µM, respectively); inhibits LPS-induced Nf-κB DNA binding in MPMs at 5 and 20 µM; inhibits the growth of various cancer cells (GI50s = 0.019-0.32 µM, respectively); reduces tumor volume and weight in a HeLa cervical mouse xenograft model at 10 mg/kg for three days; prevents LPS-induced increases in BALF total protein levels and CD68+ macrophage and neutrophil infiltration in a mouse model of LPS-induced acute lung injury at 20 mg/kg per day; reduces MPO activity in isolated neutrophils in the same model

保存温度:

-20

运输温度:

-20

预期分子量:

358.38508

产品形式:

A solid

纯度:

≥98%

CAS号:

111797-22-9