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折扣/货期| 货号：AG-CR1-3631-G001 | 规格：1 g | 目录价：￥240 |
| 货号：AG-CR1-3631-G005 | 规格：5 g | 目录价：￥420 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Menadione
别名:
Vitamin K3; NSC4170; 2-Methyl-1,4-naphthalenedione
产品描述:
Synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2 (menaquinone) after alkylation in vivo. The 1,4-naphthoquinone (NQ) moiety can form redox isomers by accepting one or two electrons respectively. The quinone redox cycling ability leads to the generation of reactive oxygen species (ROS) as well as arylation reactions. Anticancer compound. Apoptosis inducer in various cultured cells including leukemia through several modes of action. Free radical generator. Produces peroxide and superoxide radicals (ROS) leading to mitochondrial dysfunction. Cell cycle inhibitor. Glutathione (GSH) depletion results by direct arylation of cellular thiols. Once GSH is depleted, cellular macromolecules start to be alkylated, resulting in their inactivation. Protein tyrosine phosphatase inhibitor. Inhibitor of mitochondrial DNA polymerase gamma. Inhibitor of indoleamine 2,3-dioxygenase (IDO) with an IC50 of ~1µM.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
172.2
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98%
CAS号:
58-27-5
分子式:
C11H8O2
溶解度:
Soluble in DMSO (20mg/ml), ethanol (10mg/ml) or dimethylformamide (30mg/ml). Insoluble in water.
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