Metformin . HCl-抑制剂-深圳欣博盛生物科技有限公司

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Metformin . HCl

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3689-G001	规格：1 g	目录价：￥360
货号：AG-CR1-3689-G005	规格：5 g	目录价：￥540

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Metformin . HCl

别名:

1,1-Dimethylbiguanide . HCl; NSC 91485; DMGG; LA 6023

产品描述:

AMPK activator. Useful agent for immunometabolism research. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation. Mitochondrial electron transport chain complex I inhibitor, reducing mitochondrial reactive oxygen species (ROS). Antidiabetic and anti-hyperglycemic agent that reduces blood glucose levels, improves insulin sensitivity and decreases insulin resistance. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Used as weight-loss agent in obesity and as insulin sensitizer in nonalcoholic fatty liver disease (NAFLD). Leptin sensitizer to mediate the weight-loss effect in the brain. Increases plasma concentrations of the glucose-lowering gut incretin hormone glucagon-like peptide-1 (GLP-1), which may contribute to metformin's glucose-lowering effect. Anticancer agent with antiproliferative and proapoptotic activity in cancer cell lines. Autophagy activator. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Targets brown adipose tissue (BAT) in vivo and reduces oxygen consumption. Anti-inflammatory agent. Described to suppress inflammatory responses by inhibition of nuclear factor kappaB (NF-kappaB) via AMPK-dependent and independent pathways. Also described to inhibit NLRP3 inflammasome activation, subsequent caspase-1 cleavage and interleukin-1beta secretion.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

129.2 . 36.5

产品形式:

solid

产地:

瑞士

纯度:

>98%