ML-210-抑制剂-深圳欣博盛生物科技有限公司

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ML-210

品牌：Cayman

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说明书

折扣/货期

货号：23282-1 mg	规格：1 mg	目录价：￥482
货号：23282-10 mg	规格：10 mg	目录价：￥3162
货号：23282-25 mg	规格：25 mg	目录价：￥6620
货号：23282-5 mg	规格：5 mg	目录价：￥1715

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

ML-210

别名:

DPI10

产品描述:

A prodrug inhibitor of GPX4 and an inducer of ferroptosis; forms adducts with GPX4 in cells and inhibits GPX4 enzymatic activity in cell lysates but does not form adducts with recombinant human GPX4 or bind to GPX4 in a lysate-based CETSA® or a pull-down assay; induces cellular lipid hydroperoxide accumulation in LOX-IMVI cells at 10 µM, an effect that can be blocked by ferrostatin-1; induces ferroptotic cell death in LNCaP and LNCaP-AI cells, an effect that can be blocked by ferrostatin-1 or liproxstatin-1; selectively induces Ras-synthetic lethality in mutant RAS oncogene-expressing cells (IC50s = 71 and 272 nM in HRASG12V-expressing and wild-type RAS-expressing BJeH cells, respectively)

保存温度:

-20

运输温度:

-20

预期分子量:

475.3

产品形式:

A crystalline solid

纯度:

≥98%

CAS号:

1360705-96-9