MLL2 Antibody / KMT2D-多抗-深圳欣博盛生物科技有限公司

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MLL2 Antibody / KMT2D

品牌：NSJ Bio

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说明书

折扣/货期

货号：F53759-0.4ML	规格：0.4 ml	目录价：￥6344
货号：F53759-0.08ML	规格：0.08 ml	目录价：￥2962

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MLL2 Antibody / KMT2D

产品描述:

The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family, including MLL2. The MLL SET domain is a histone H3 Lys4 (K4)-specific methyltransferase whose activity is stimulated with acetylated H3 peptides. The gene for MLL2 encodes a 5,262-amino acid protein containing a SET domain, 5 PHD fingers, potential zinc fingers, and a long run of glutamines interrupted by hydrophobic residues (mostly leucine). They also detected an alternatively spliced form encoding 4,957 amino acids and lacking an N-terminal zinc finger and PHD finger. By analysis of rodent/human hybrid cells and analysis of the Genebridge radiation hybrid panel, they mapped the gene to the 12p13.1-qter region. The 12q12-q13 region is involved in duplications and translocations associated with cancer. By database searching, Karlin et al. (2002) identified 192 human protein sequences that have multiple amino acid runs, many of which are associated with disease, including cancer. Karlin et al. (2002) found that a key aspect of 82 of these protein sequences is their role in transcription, translation, and developmental regulation. MLL2 is a striking example of proteins with multiple amino acid runs, with 22 glutamine runsGenes encoding a significant number of long amino acid runs are potentially associated with diseases, such as cancer.

反应种属:

Human

宿主来源:

Rabbit

实验应用:

WB, IHC-P, ELISA

同种型:

Rabbit Ig

免疫原:

A portion of amino acids 4980-5009 from the human protein was used as the immunogen for this MLL2 antibody.

克隆性:

Polyclonal (rabbit origin)