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折扣/货期| 货号：AG-CS1-0103-M001 | 规格：1 mg | 目录价：￥2700 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
MLN4924 Solution
别名:
Pevonedistat; Nedd8 E1 Activating Enzyme Inhibitor; TAK924
产品描述:
Adenosine 5'-monophosphate (AMP) analog. Potent, selective and cell permeable inhibitor of Nedd8 E1 Activating Enzyme (NAE) (IC50=4.7nM). NEDD8 is an ubiquitin-like protein whose activity is required to activate cullin-RING ubiquitin E3 ligases (CRLs) responsible for the ubiquitination and proteasome-dependent turnover of certain substrates relevant to cancer cell survival. Anticancer agent with in vitro and in vivo activity. By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis. Inhibits related enzymes ubiquitin-activating enzyme (UAE) and SUMO-activating enzyme (SAE) with IC50 values of 1.5 and 8.2µM, respectively. Angiogenesis inhibitor and autophagy inducer. Antiviral agent. Exhibited pronounced antiviral activity against mouse and human cytomegalovirus, herpes simplex virus (HSV)- 1 (including multi-drug resistant clinical isolates), HSV-2, adeno and influenza viruses.
保存温度:
-20°C
运输温度:
BI
预期分子量:
443.5
产品形式:
liquid
存储溶液:
20mM stock solution in DMSO.
有效期:
Stock solutions are stable for at least 3 months when stored at -20°C.
产地:
瑞士
纯度:
>99% (HPLC)
CAS号:
905579-51-3
分子式:
C21H25N5O4S
促销活动
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