MYLK3 Antibody / Myosin light chain kinase 3-多抗-深圳欣博盛生物科技有限公司

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MYLK3 Antibody / Myosin light chain kinase 3

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：F40165-0.08ML	规格：0.08 ml	目录价：￥2962.25
货号：F40165-0.4ML	规格：0.4 ml	目录价：￥6343.55

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MYLK3 Antibody / Myosin light chain kinase 3

产品描述:

MYLK3, a member of the Ser/Thr protein kinase family, is a calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.

反应种属:

Human, Mouse

宿主来源:

Rabbit

实验应用:

IHC, WB, ELISA

同种型:

Rabbit Ig

免疫原:

A portion of amino acids 40-69 from the human protein was used as the immunogen for this MYLK3 antibody.

克隆性:

Polyclonal (rabbit origin)