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折扣/货期| 货号：AG-40A-0018AA-C500 | 规格：500 ug | 目录价：￥30000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Nampt (Visfatin/PBEF) (human) (rec.) (His) (BULK)
别名:
Pre-B Cell Colony Enhancing Factor 1; PBEF1; Nicotinamide Phosphoribosyltransferase
产品描述:
Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity. Recently NAMPT extracellular (eNAMPT) has been shown to be secreted from macrophages in muscles and to triggers a proliferative signal of muscle stem cell (MusC) by binding to CCR5 located at the surface receptor of MusC.
宿主来源:
E. coli
保存温度:
+4°C
运输温度:
BI
预期分子量:
~52kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized.
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>90% (SDS-PAGE)
生物活性:
Shows adipogenic effects in stimulated differentiating 3T3-L1 cells.
内毒素水平:
<1EU/µg purified protein (LAL test; Lonza).
促销活动
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