| 货号:22409-1 mg | 规格:1 mg | 目录价:¥549 |
| 货号:22409-10 mg | 规格:10 mg | 目录价:¥4181 |
| 货号:22409-25 mg | 规格:25 mg | 目录价:¥8831 |
| 货号:22409-5 mg | 规格:5 mg | 目录价:¥2385 |
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
Nazartinib
产品描述:
An inhibitor of mutant EGFRs; selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 NSCLC cells (IC50 = 4.18 nM), over cells expressing wild-type EGFR (IC50 = 160.6 nM for HaCaT keratinocytes); decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM) and inhibits cell proliferation of H3255, HCC827, and H1975 cells (EC50s = 9, 11, and 25 nM) but does not affect cell proliferation in cell lines containing wild-type EGFR; reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model at doses ranging from 3 to 100 mg/kg per day
保存温度:
-20
运输温度:
-20
预期分子量:
495
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
1508250-71-2
分子式:
C26H31ClN6O2
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