Niclosamide-抑制剂-深圳欣博盛生物科技有限公司

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Niclosamide

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3643-G001	规格：1 g	目录价：￥600
货号：AG-CR1-3643-M100	规格：100 mg	目录价：￥360

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Niclosamide

别名:

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; 2′,5-Dichloro-4′-nitro-salicylanilide; BAY-2353; Bayluscid; Cestoid; HL2447; Yomesan

产品描述:

Antihelminthic, molluscicide and trypanocidal agent that inhibits mitochondrial oxidative phosphorylation and anaerobic ATP production. Anticancer agent with antiproliferative activity in a broad spectrum of cancer cells. Targets and inhibits multiple signaling pathways, including STAT3, NF-kB, Wnt/beta-catenin, Notch and mTORC1. Shown to block TNF-alpha-induced IkappaBalpha phosphorylation, translocation of p65 and the expression of NF-kappaB-regulated genes and elevates reactive oxygen species (ROS) levels. Promotes Frizzled1 internalization, down-regulates the expression of Dishevelled-2 protein and inhibits beta-catenin stabilization. Inhibits mTORC1 but not mTORC2 signaling in cells maintained in nutrient-rich conditions. Cell permeable selective STAT3 inhibitor (IC50=0.25µM). Inhibits the activation, nuclear translocation and transactivation of STAT3. Selective over STAT1, STAT5, JAK1, JAK2 and Src kinases. Induces cell cycle arrest, growth inhibition, autophagy and apoptosis. Inhibits S100A4 (Metastasin-1)-induced metastasis in vivo. Inhibits androgen receptor (AR) splice variants. Anti-inflammatory compound. Quorum sensing inhibitor. Broad-spectrum antiviral agent that targets acidified endosomes. Has been shown to inhibit replication of SARS and is a potential candidate to treat SARS-CoV-2 (COVID-19) infections. Antiobesity and antidiabetic agent. Positive allosteric neuropetide Y4 receptor ligand and increases energy expenditure and lipid metabolism through mitochondrial uncoupling.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

327.1

产品形式:

solid

产地:

瑞士

纯度:

>95%