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折扣/货期| 货号：60-959 | 规格：400 ul | 目录价：￥8687.25 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
NPC1L1 Antibody
别名:
Niemann-Pick C1-like protein 1, NPC1L1
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit Ig
克隆性:
Polyclonal
纯化方式:
This antibody is purified through a protein A column, followed by peptide affinity purification.
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
Supplied in PBS with 0.09% (W/V) sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
The protein encoded by this gene is a multi-pass membrane
protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1)
domain and a putative sterol-sensing domain (SSD) which includes a
YQRL motif functioning as a plasma membrane to trans-Golgi network
transport signal in other proteins. This protein takes up free
cholesterol into cells through vesicular endocytosis and plays a
critical role in the absorption of intestinal cholesterol. It also
has the ability to transport alpha-tocopherol (vitamin E). The drug
ezetimibe targets this protein and inhibits the absorption of
intestinal cholesterol and alpha-tocopherol. In addition, this
protein may play a critical role in regulating lipid metabolism.
Polymorphic variations in this gene are associated with plasma
total cholesterol and low-density lipoprotein cholesterol (LDL-C)
levels and coronary heart disease (CHD) risk. Alternatively spliced
transcript variants encoding different isoforms have been found for
this gene.
Accession #:
Q9UHC9
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