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折扣/货期| 货号：22142-1 mg | 规格：1 mg | 目录价：￥590 |
| 货号：22142-10 mg | 规格：10 mg | 目录价：￥4047 |
| 货号：22142-25 mg | 规格：25 mg | 目录价：￥9326 |
| 货号：22142-5 mg | 规格：5 mg | 目录价：￥2157 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
NVP-BGT226
产品描述:
A dual PI3K and mTOR inhibitor (EC50s = 4, 63, and 38 nM for PI3Kα, β, and γ isoforms, respectively, in a filter binding assay); binds to class I and class III PI3Ks (EC50s = 55.8 and 7.03 nM, for HsPI3Kβ and HsVps34, respectively); decreases protein levels of phosphorylated mTOR and Akt; inhibits the growth of squamous cell carcinoma cell lines, HONE-1, and a variant of HONE-1 resistant to cisplatin (IC50s = 7.4-27.8, 22.6, and 30.1 nM, respectively); inhibits tumor growth in a FaDu mouse xenograft model at doses of 2.5 and 5 mg/kg daily for three weeks
保存温度:
-20
运输温度:
-20
预期分子量:
534.532549
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
1245537-68-1
分子式:
C28H25F3N6O2 • C4H4O4
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