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折扣/货期| 货号：40785-1 mg | 规格：1 mg | 目录价：￥1166 |
| 货号：40785-10 mg | 规格：10 mg | 目录价：￥7584 |
| 货号：40785-25 mg | 规格：25 mg | 目录价：￥13105 |
| 货号：40785-5 mg | 规格：5 mg | 目录价：￥4663 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
NX-2127
产品描述:
A PROTAC that drives BTK, IKZF1, and IKZF3 degradation; induces degradation of wild-type BTK, BTKC481S, BTKV416L, BTKT474I, and BTKL528W in TMD8 DLBCL cells (DC50s = 1.9, 9.7, 4.2, 2.4, and 1.9 nM, respectively); degrades IKZF1 and IKZF3 (DC50s = 57 and 36 nM, respectively) and induces T cell activation in primary human T cells stimulated by anti-CD3 and anti-CD28 antibodies; reduces BTK levels in circulating mouse B cells to 12% of baseline at 30 mg/kg; induces intratumoral BTK, IKZF1, and IKZF3 degradation in a TMD8 mouse xenograft model at 10, 30, and 90 mg/kg per day; reduces tumor growth in mouse xenograft models using TMD8 cells expressing wild-type BTK or BTKC481S
保存温度:
-20
运输温度:
-20
预期分子量:
719.83226
产品形式:
A solid
纯度:
≥95%
CAS号:
2416131-46-7
分子式:
C39H45N9O5
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