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折扣/货期| 货号：35297-10 mg | 规格：10 mg | 目录价：￥1327 |
| 货号：35297-25 mg | 规格：25 mg | 目录价：￥3162 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ONO-8590580
产品描述:
A negative allosteric modulator of α5 subunit-containing GABAA receptors that binds at the benzodiazepine binding site; binds to α1, α2, α3, and α5 subunit-containing GABAA receptors (Kis = 140, 32, 24, and 7.9 nM, respectively); selective for inhibiting GABA-induced currents in HEK293 cells expressing α5β3γ2 subunits (EC50 = 1.1 nM) over those expressing α1β3γ2, α2β3γ2, or α3β3γ2 subunits; enhances long-term potentiation in rat hippocampal brain slices at 300 nM; decreases MK-801-induced memory deficits in the rat passive avoidance test at 3-20 mg/kg; decreases MK-801- and scopolamine-induced increases in the latency to complete, and the number of errors made in, the eight-arm radial maze in rats at 20 mg/kg; does not induce anxiety-like or proconvulsant behavior in rats in the elevated zero maze or pentylenetetrazole-induced seizure test at 20 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
376.430283
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
1802661-73-9
分子式:
C21H21FN6
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