p53 (polyubiquitinated) (human) (rec.) (His)-其他重组蛋白-深圳欣博盛生物科技有限公司

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p53 (polyubiquitinated) (human) (rec.) (His)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：SBB-US0012-C020

规格：20 ug

目录价：￥7672

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

p53 (polyubiquitinated) (human) (rec.) (His)

别名:

Cellular Tumor Antigen p53; Tumor Suppressor p53; TP53

产品描述:

p53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. E3 ligase MDM2 mediated ubiquitin conjugation of p53 and subsequent p53 down-regulation via proteasomal degradation interrupts this crucial role, contributing to tumorogenesis (and cancer).

宿主来源:

E. coli

产品浓度:

Lot dependent.

保存温度:

-80°C

运输温度:

Dry Ice

预期分子量:

>40kDa. Western blot analysis shows multiple states of poly-ubiquitination, and deconjugation with USP7 shows purified ubiquitinated p53 can function as a native substrate.

产品形式:

liquid

存储溶液:

Liquid. In 50mM HEPES pH 7.5, 500 mM sodium chloride, 10% glycerol, 2mM TCEP.

产地:

瑞士

纯度:

>95% (SDS-PAGE)

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