| 货号:R31058 | 规格:100 ug | 目录价:¥6488.05 |
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
p62 Antibody / SQSTM1
产品描述:
Sequestosome-1, also known as Ubiquitin-Binding Protein p62, is a protein that in humans is encoded by the SQSTM1 gene. The Src homology type 2(SH2) domain is a highly conserved motif of about 100 amino acids which mediates protein-protein interactions by binding to phosphotyrosine.p56-lck, a T-cell-specific src family tyrosine kinase with an SH2 domain, is involved in T-cell signal transduction. The International Radiation Hybrid Mapping Consortium mapped the p62 gene to chromosome 5q35. Park et al.(1995) found that the p56-lck SH2 domain binds p62 at the ser59 only when that serine is phosphorylated. Joung et al.(1996) expressed epitope-tagged p62 in Hela cells and showed that the expressed protein bound to the lck SH2 domain and that this binding was dependent on the N-terminal 50 amino acids of p62 but not on the tyrosine residue in this region.
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
WB, IHC-P, ICC, IF, FACS
同种型:
Rabbit IgG
免疫原:
An amino acid sequence from the N-terminus of human SQSTM1 (KDDIFRIYIKEKKECRRDHR) was used as the immunogen for this p62 antibody.
克隆性:
Polyclonal (rabbit origin)
纯化方式:
Antigen affinity
保存温度:
After reconstitution, the p62 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
产品形式:
Antigen affinity purified
存储溶液:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
产地:
美国
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